Within 15-30 minutes after exposure to high doses of MSG, the neurons suspended in tissue culture are seen to swell up like balloons. You can see the degeneration of the small structures within the cell under the microscope, called organelles. You will also see clumping of the chromatin of the nucleus. Within 3 hours these neurons are not only dead, but the body’s defense mechanisms begin to haul away the debris. The degenerative reaction is seen under experimental conditions using animals when the MSG is either ingested via the diet, injected in the abdominal cavity or applied directly to the neurons in tissue culture into the brain via the cannula or tube.

Glutamate and Aspartate appear to work by opening calcium channels on certain subtypes of receptors. When these neurotransmitters are allowed to come into contact with the receptor in too high of a concentration or for too long a period of time, the calcium channel gets stuck in the open position, allowing calcium to pour into the cell in large amounts. When this happens the protective mechanisms are triggered. But as with the glutamate pumps, the calcium pumps also require large amounts of energy as ATP. This energy must be supplied continuously, especially if the calcium continues to enter in large amounts and for a prolonged period of time. Again, it’s like bailing out a boat that has a large hole in the bottom. To keep from sinking you must bail the water out faster than it flows into the boat. If you have ever been in this position you’ll know that it takes a lot of energy to do this.

So how does calcium actually kill the cell? This is an area of intense research and interest because these calcium channels appear to play an important part in a multitude of seemingly unrelated diseases, such as strokes, heart attacks, arthritis, brain injury, migraine headaches and cancer.

Summary

In a nutshell: MSG enters the brain past the blood-brain barrier, triggers neurons to open their calcium channel, the glutamate causes the cell to remain stuck in the open position then calcium floods into the cell in large amounts. This triggers the cell to react in emergency mode and starts it’s special pump that will start pumping out the excess calcium using up large amounts of energy (ATP), the cell swells up with excess calcium and eventually the cell is depleted of energy and dies within two hours. The pump couldn’t pump out the excess calcium fast enough. (It’s like trying to bail water out of a boat with a large hole in the bottom. You use up a ton of energy and eventually the boat is filled and sinks). The cell shrivels up and the body’s defense mechanism sweeps away the dead cell debris.

Excerpts from: Excitoxins: The Taste that Kills. Russell Blaylock M.D.

MSG-laced

I’m sure you already know that tortilla and potato chips aren’t health foods, right? They’re made with fried fats, they almost always harbor hidden toxic chemicals (acrylamides), and if they’re flavored, they usually contain monosodium glutamate (MSG). This is basically a recipe for obesity.

But how does MSG cause obesity? Like aspartame, MSG is an excitotoxin, a substance that overexcites neurons to the point of cell damage and, eventually, cell death. Humans lack a blood-brain barrier in the hypothalamus, which allows excitotoxins to enter the brain and cause damage, according to Dr. Russell L. Blaylock in his book Excitotoxins. According to animal studies, MSG creates a lesion in the hypothalamus that correlates with abnormal development, including obesity, short stature and sexual reproduction problems.

Based on this evidence, Dr. Blaylock makes an interesting point about the American obesity epidemic, especially among young people: “One can only wonder if the large number of people having difficulty with obesity in the United States is related to early exposure to food additive excitotoxins, since this obesity is one of the most consistent features of the syndrome. One characteristic of the obesity induced by excitotoxins is that it doesn’t appear to depend on food intake. This could explain why some people cannot diet away their obesity.” As an increasing number of elementary school students bring snack-size bags of chips to school in their lunch boxes, the MSG-obesity link demands parental caution.

Instead of passively watching modern society become obese and then commenting on it, we need to change it at the start. That begins with you, the consumer. By avoiding foods with MSG, you are not only protecting your health and your family’s health, you are also protecting society’s health by not supporting companies that use MSG. Use your buying power to show that you don’t accept manufactured foods that use MSG or any of the other hidden forms of MSG such as yeast extract, hydrolyzed vegetable proteins and autolyzed proteins.

The experts speak on MSG and obesity:

Olney, J.W. “Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium glutamate.” Sci. 165(1969): 719-271. Humans also lack a blood-brain barrier in the hypothalamus, even as adults. It is for this reason that Dr. Olney and other neuroscientists are so concerned about the widespread and heavy use of excitotoxins, such as MSG, hydrolyzed vegetable protein, and cysteine, as food additives. In his experiments Dr. Olney found that high-dose exposure to MSG caused hypoplasia of the adenohypophysis of the pituitary and of the gonads, in conjunction with low hypothalamic, pituitary, and plasma levels of LH, growth hormone, and prolactin. When doses below toxic levels for hypothalamic cells were used, he found a rapid elevation of LH and a depression of the pulsatile output of growth hormone. In essence, these excitotoxins can cause severe pathophysiological changes in the central endocrine control system. Many of these dysfunctional changes can occur with subtoxic doses of MSG. One can speculate that chronic exposure to these neurotoxins could cause significant alterations in the function of the hypothalamus, including its non-endocrine portions.
Excitotoxins by Russell L Blaylock MD, page 263

“Consuming MSG leads to obesity”

Early exposure in life to high doses of glutamate, or the other excitotoxins, could theoretically produce a whole array of disorders much later in life, such as obesity, impaired growth, endocrine problems, sleep difficulties, emotional problems including episodic anger, and sexual psycho-pathology.
Excitotoxins by Russell L Blaylock MD, page 89

The stress-induced abnormalities in blood-brain barrier permeability suggest differing MSG effects dependent on existing states of relaxation or stresses. The suggestive evidence for MSG-induced neuroendocrine effects is substantial, coupled with the observation of increased obesity in children.
In Bad Taste by George R Schwartz MD, page 39

With this enormous consumption of foods laced with MSG additives, it is no wonder that we have an obesity problem in this country, especially when you combine the hypothalamic lesion caused by MSG to the high-fat and -carbohydrate diets of young people. Of particular concern is the suggestion that MSG ingested by pregnant women may actually cause this lesion in children while they are still in the womb.
Health And Nutrition Secrets by Russell L Blaylock MD, page 180

This also means that, while pregnant, mothers of diabetic children also consumed very large amounts of these excitotoxin-containing foods. Also, many parents feed their babies table food from an early age—food often laced with large amounts of MSG. In addition, large numbers of babies are also fed formula, and many formulas are known to be high in excitotoxins such as caseinate. I have already cited studies showing that gross obesity is frequently linked to excessive MSG consumption in test animals.
Health And Nutrition Secrets by Russell L Blaylock MD, page 182

Particularly disturbing is the later obesity after MSG exposure during the neonatal and infant period even after only a short or limited exposure.
In Bad Taste by George R Schwartz MD, page 22

With all of these endocrine malfunctions you would expect these mice to develop abnormally, and they do. Consistently, the animals exposed to MSG were found to be short, grossly obese, and had difficulty with sexual reproduction. One can only wonder if the large number of people having difficulty with obesity in the United States is related to early exposure to food additive excitotoxins since this obesity is one of the most consistent features of the syndrome. One characteristic of the obesity induced by excitotoxins is that it doesn’t appear to depend on food intake. This could explain why some people cannot diet away their obesity. It is ironic that so many people drink soft drinks sweetened with NutraSweet® when aspartate can produce the exact same lesions as glutamate, resulting in gross obesity. The actual extent of MSG induced obesity in the human population is unknown.
Excitotoxins by Russell L Blaylock MD, page 81

“Animal studies demonstrate link between MSG and obesity”

The obesity effect of MSG in animals requires evaluation since unexplained obesity is increasing in our population, along with hypertension and diabetes. MSG-induced obesity in animals may carry long-term significance for humans.
In Bad Taste by George R Schwartz MD, page 22

Since his early observation, other studies have confirmed that MSG causes gross obesity in animals. At an international neuroscience meeting, Dr. Olney was asked if he thought the reason Americans were so obese was, in fact, due to their high consumption of MSG additives. The question was never answered, but since that conference in the 1970s, America has undergone this virtual epidemic of gross obesity, especially among its youth.
Health And Nutrition Secrets by Russell L Blaylock MD, page 180

This MSG-induced obesity was characterized by a preference for carbohydrates and an aversion for more nutritious foods, just as we are now witnessing in our youth. Also, excess weight was extremely difficult to exercise off or diet off in these experimental animals.
Health And Nutrition Secrets by Russell L Blaylock MD, page 182

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